Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.

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Lack of clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality.

Macular Amyloidosis (Friction Amhyloidosis)

Occasionally, more number of amcular keratinocytes were found overlying the subepidermal amyloid deposits. You may experience pain, numbness or tingling of the fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.

However, as treatment follow-up lasted only two months, possible side effects such as residual hypopigmentation were not identified, particularly in patients with phototypes V or VI, for whom six months follow-up after the multiple laser sessions would be required.

Histopathological examination of the cutaneous lesion revealed significant quantities of an amyloid deposit in the papillary dermis, which could be more clearly observed after Congo red staining, as well as foci of pigmentary incontinence.

Clinical manifestations and diagnosis of amyloid cardiomyopathy. It is also important to know that both lichen amyloidosis and macular amyloidosis share the ability to stain positive for antikeratin antibodies. Amyloidosis; Congo Red; Hyperpigmentation. Some people with amyloidosis experience purpura macjlar a condition in which small blood vessels leak blood into the skin, causing purplish patches. Many names for the same clinical entity.

However, there is evidence linking primary localized cutaneous amyloidoses to a variety of immune disorders including systemic sclerosis, CREST syndrome, rheumatoid arthritis, systemic lupus erythematosus, amuloidosis biliary cirrhosis, autoimmune cholangitis, Kimura disease, ankylosing spondylitis, autoimmune thyroiditis, IgA nephropathy, and sarcoidosis.


J Am Acad Dermatol. This case study describes an uncommon form of MA because of the location and extent of the lesions.

Structures and biological functions amiloidsis IL amipoidosis IL receptors. Macular amyloidosis MA is a rare chronic form of cutaneous amyloidosis see this terma skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper amuloidosis and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis.

Dermabrasion, CO2 laser, and pulse dye laser provide alternative options for patients unresponsive to other treatments.

Clinical, laboratorial and histopathological study of 25 cases. In the patient studied here this failed amillidosis reveal any abnormal results. Congo Red shows apple-green birefringence under polarized light Methyl or cresyl violet Thioflavin T with examination using fluorescence microscopy.

In mild cases, topical corticosteroids have been beneficial. Rajkumar SV, et al. Additionally, there is some evidence in the literature promoting the use of phototherapy for primary localized cutaneous amyloidosis. There is an unclear link between primary localized cutaneous amyloidoses and a variety of immune disorders including systemic sclerosis, CREST syndrome, rheumatoid arhritis, systemic lupus erythematosus, primary biliary cirrhosis, autoimmune cholangitis, Kimura disease, ankylosing spondylitis, autoimmune thyroiditis, IgA nephropathy, and sarcoidosis.

There are also reports of rare hypochromic and poikilodermatous forms 4. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. In our study, smiloidosis was a wide variation in the duration of the disease at the time of presentation 1 month yearsand about half of the amiloidisis presented within 2 years of appearance of the lesions.

Flat, dusky brown patch of upper back 2: Cause – effect relationship? Patient education is important in breaking the itch-scratch-itch cycle.

A Clinico-Epidemiological Study of Macular Amyloidosis from North India

It is the most subtle form of cutaneous amyloidosis and tends to persist unchanged for many years. Accessed April 27, Which of the following best describes your experience with hand-foot-and-mouth disease? Primary cutaneous amiloidoxis PCA has an incidence that varies significantly with ethnic origin and is more common in South America and Asia than in North America and Europe.


Amyloidoses can be systemic or localized. Palitz LL, Peck S. The specific cause of your condition depends on the type of amyloidosis you have. Macular amyloid on the back. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Macular amyloidosis simulating naevoid hyperpigmentation.

Macular amyloidosis MA was first described maculwr by Palitz and Peck. It is achieved by direct intradermal injection of these antiamyloid antibodies.

Macular Amyloidosis (Friction Amhyloidosis)

A skin biopsy stained with hematoxylin and eosin typically demonstrates amorphous deposits of eosinophilic material amyloid deposits within the papillary dermis. Two theories, fibrillar body theory and kacular theory, have been proposed. Histopathological findings from the 26 biopsies undertaken and studied are summarized. Clinical presentation, laboratory manifestations and diagnosis of immunoglobulin light chain AL amyloidosis primary amyloidosis.

The natural course of the disease is not well described. Discussion Amyloidosis is an extra-cellular deposition of the fibrous protein either involving multiple organ systems systemic amyloidosis or restricted to a single-tissue site localized amyloidosis. After systemic involvement had been excluded, topical photoprotection was started and the patient was followed up.

The observation about the role of friction could not be conclusively supported or negated.

The use of nylon towels or brushes on the skin has also been described as amiloiidosis risk factor for the development of MA. Touart DM, Sau P. Hashimoto K, Kobayashi H. However, the relationship if any between history of atopy and MA has not been either confirmed or explained.