This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour. The ethosomes are vesicular carrier comprise of hydroalcoholic or hydro/ alcoholic/glycolic phospholipid in which the concentration of alcohols or their. Ethosomes as novel drug delivery system: A review. Prasad V Patrekar, Suhel J Inamdar, Sachin S Mali, Mulla T Mujib,. Amita A Ahir, Avinash.

Author: Shakasar Gugami
Country: Iceland
Language: English (Spanish)
Genre: Art
Published (Last): 5 July 2013
Pages: 271
PDF File Size: 16.25 Mb
ePub File Size: 16.26 Mb
ISBN: 390-5-70929-227-6
Downloads: 15077
Price: Free* [*Free Regsitration Required]
Uploader: Kagakree

The traditional can be localized at the site of action, reducing transdermal drug delivery systems involve a the systemic side effects.

Ethosomes as novel drug delivery system: Drug formulation with elastic vesicle or skin enhances vesicles. Ethosome composition is safe and the components are approved for pharmaceutical and cosmetic use. Ethosomes are platform for the delivery of large and diverse group of drugs peptides, protein molecules.

Ethosomes, ethanol, composition, transdermal drug delivery Abstract: Help Center Find new research papers in: Journal of Control Release ; This can quantify by high PharmaTutor Magazine Vol. One of the major advances in vesicle research was the finding a vesicle derivatives, known as an Ethosomes.

Transdermal applications of ethosomes – a detailed review.

Ethosomal carrier opens new challenges and opportunities for the development of novel improved therapies. Liposomes, permeability of drug through the stratum niosomes, transferosomes and ethosomes also corneum barrier. B, Bhadra D, Jain N. Can’t read the image? Ethosomes have been tested to encapsulate hydrophilic drugs, cationic drugs, proteins and peptides. Oestradiol skin delivery from ultra deformable liposomes: The literature is abounding with attempts made to enhance the delivery of drugs into the deep layers of the skin and through the skin.


All Published work is licensed under a Creative Commons Attribution 4. Vesicle skin interaction study showed that ethosomes rthosomes the ultrastructure of the stratum corneum as distinct regions with lamellar stacks derived from 5the vesicles were observed in the intercellular spaces of the stratum corneum.

Enter the email address you signed up with and we’ll email you a reset link.


Preparation of ethosomes is easy with no complicated equipment involved and therefore can be scaled up to industrial level. Schreier H, Bovwstra J.

They are composed mainly of phospholipids, phosphatidylcholine, phosphatidylserine, phosphatitidic acidhigh concentration of ethanol and water. Ethosomes were designed to enhance the delivery of drugs into the reviea layers of the skin and through the skin. Ethosomes-novel vesicular carriers for enhances.

However ethosomes prepared by sonication method were more uniform and smaller in size, which is essential for skin permeation. Ethosomes are provides a number of important benefits including improving the drug’s efficacy, enhancing patient compliance and comfort and reducing the total cost of treatment. Touitou E, Drug delivery across the skin, Expert Opin.


To confirm the better skin permeability of ethosomes, fluorescence microscopy using rhodamine as fluorescence probe was performed. Various application in Pharmaceutical, Veterinary, Cosmetic field.

Ethosomes and its Applications in Transdermal Drug Delivery | BenthamScience

Ethosomes can be prepared from soybean phosphatidylcholine Phospholipon 90ethanol, drug and distilled water. Dayan N, Touitou E. Ethosomes have been found to be much more efficient at delivering drug to the skin, than either liposomes or hydroalcoholic solution.

The size ethosoms vesicles were found to be in the range of 3. Transdermal drug delivery offers many advantages as compared to traditional drug delivery systems, including oral and parenteral drug delivery system.